I used Copic markers. For my diary strips, those are more throwaway, so I did them digitally. With bigger pieces, I use Copics, pencil crayons, and I want to start in with water colours too. Digital always looks digital, and it's what 90% of people use, so that's reason enough not to do it
I agree, that's why I have started using markers as well. Quality can be variable but I think the scanning process is key. I have a lot of optimisation to do yet I think! I've used watercolours a bit as well and they can be great but the vibrancy never transferred well to a computer screen for me. I look forward to seeing how you get on!